Ontology highlight
ABSTRACT:
SUBMITTER: Schneider RK
PROVIDER: S-EPMC4199102 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Cancer cell 20140918 4
The casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the common deleted region for del(5q) myelodysplastic syndrome (MDS). We generated a murine model with conditional inactivation of Csnk1a1 and found that Csnk1a1 haploinsufficiency induces hematopoietic stem cell expansion and a competitive repopulation advantage, whereas homozygous deletion induces hematopoietic stem cell failure. Based on this finding, we found that heterozygous inactivation of Csnk1a1 sensitiz ...[more]