Glucocorticoid receptors in the retina, Muller glia and the formation of Muller glia-derived progenitors.

ABSTRACT: Identification of the signaling pathways that influence the reprogramming of Müller glia into neurogenic retinal progenitors is key to harnessing the potential of these cells to regenerate the retina. Glucocorticoid receptor (GCR) signaling is commonly associated with anti-inflammatory responses and GCR agonists are widely used to treat inflammatory diseases of the eye, even though the cellular targets and mechanisms of action in the retina are not well understood. We find that signaling through GCR has a significant impact upon the ability of Müller glia to become proliferating Müller glia-derived progenitor cells (MGPCs). The primary amino acid sequence and pattern of GCR expression in the retina is highly conserved across vertebrate species, including chickens, mice, guinea pigs, dogs a

SUBMITTER: Gallina D 

PROVIDER: S-EPMC4199119 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature