Circulating cortisol-associated signature of glucocorticoid-related gene expression in subcutaneous fat of obese subjects.

ABSTRACT:

Objective

Serum cortisol concentrations fluctuate in a circadian fashion, and glucocorticoids exert strong effects on adipose tissue and induce obesity through the glucocorticoid receptor.

Design and methods

To examine the impact of physiologic levels of circulating cortisol on subcutaneous adipose tissue, 25 overweight and obese subjects were employed, and their serum levels of morning (AM) and evening (PM) cortisol, AM/PM cortisol ratios, and 24-h urinary-free cortisol (UFC) were compared with their clinical parameters, serum cytokine levels, and mRNA expression of 93 receptor action-regulating and 93 glucocorticoid-responsive genes in abdominal subcutaneous fat.

Results and conclusions

AM cortisol levels did not correlate with mRNA expression of the all genes exami

SUBMITTER: Pavlatou MG 

PROVIDER: S-EPMC4199221 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature