Homeostatic structural plasticity can account for topology changes following deafferentation and focal stroke.

ABSTRACT: After brain lesions caused by tumors or stroke, or after lasting loss of input (deafferentation), inter- and intra-regional brain networks respond with complex changes in topology. Not only areas directly affected by the lesion but also regions remote from the lesion may alter their connectivity-a phenomenon known as diaschisis. Changes in network topology after brain lesions can lead to cognitive decline and increasing functional disability. However, the principles governing changes in network topology are poorly understood. Here, we investigated whether homeostatic structural plasticity can account for changes in network topology after deafferentation and brain lesions. Homeostatic structural plasticity postulates that neurons aim to maintain a desired level of electrical activity by del

SUBMITTER: Butz M 

PROVIDER: S-EPMC4199279 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature