Efficacy and safety of bone marrow cell transplantation for chronic ischemic heart disease: a meta-analysis.

ABSTRACT:

Background

Although bone marrow-derived cells (BMCs) have shown great therapeutic potential in patients with chronic ischemic heart disease (CIHD), the exact efficacy and safety of BMCs therapy is still not completely defined.

Material/methods

We searched PubMed, OVID, EMBASE, the Cochrane Library, and ClinicalTrials.gov and finally identified 20 qualified trials in this meta-analysis. Assessment of efficacy was based on left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV), and left ventricular end-diastolic volume (LVEDV) improvement, by weighted mean difference (WMD) with 95% confidence intervals (CIs). RESULTS of all-cause death, ventricular arrhythmia, recurrent myocardial infarction, and cerebrovascular accident were pooled to assess s

SUBMITTER: Xiao C 

PROVIDER: S-EPMC4199404 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature