Signature gene expression reveals novel clues to the molecular mechanisms of dimorphic transition in Penicillium marneffei.

ABSTRACT: Systemic dimorphic fungi cause more than one million new infections each year, ranking them among the significant public health challenges currently encountered. Penicillium marneffei is a systemic dimorphic fungus endemic to Southeast Asia. The temperature-dependent dimorphic phase transition between mycelium and yeast is considered crucial for the pathogenicity and transmission of P. marneffei, but the underlying mechanisms are still poorly understood. Here, we re-sequenced P. marneffei strain PM1 using multiple sequencing platforms and assembled the genome using hybrid genome assembly. We determined gene expression levels using RNA sequencing at the mycelial and yeast phases of P. marneffei, as well as during phase transition. We classified 2,718 genes with variable expression across co

SUBMITTER: Yang E 

PROVIDER: S-EPMC4199489 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature