Spectral signatures of reorganised brain networks in disorders of consciousness.

ABSTRACT: Theoretical advances in the science of consciousness have proposed that it is concomitant with balanced cortical integration and differentiation, enabled by efficient networks of information transfer across multiple scales. Here, we apply graph theory to compare key signatures of such networks in high-density electroencephalographic data from 32 patients with chronic disorders of consciousness, against normative data from healthy controls. Based on connectivity within canonical frequency bands, we found that patient networks had reduced local and global efficiency, and fewer hubs in the alpha band. We devised a novel topographical metric, termed modular span, which showed that the alpha network modules in patients were also spatially circumscribed, lacking the structured long-distance inte

SUBMITTER: Chennu S 

PROVIDER: S-EPMC4199497 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature