Impact of Schistosoma mansoni on malaria transmission in Sub-Saharan Africa.

ABSTRACT:

Background

Sub-Saharan Africa harbors the majority of the global burden of malaria and schistosomiasis infections. The co-endemicity of these two tropical diseases has prompted investigation into the mechanisms of coinfection, particularly the competing immunological responses associated with each disease. Epidemiological studies have shown that infection with Schistosoma mansoni is associated with a greater malaria incidence among school-age children.

Methodology

We developed a co-epidemic model of malaria and S. mansoni transmission dynamics which takes into account key epidemiological interaction between the two diseases in terms of elevated malaria incidence among individuals with S. mansoni high egg output. The model was parameterized for S. mansoni high-risk endemic co

SUBMITTER: Ndeffo Mbah ML 

PROVIDER: S-EPMC4199517 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature