Immunologic predictors of coronary artery calcium progression in a contemporary HIV cohort.

ABSTRACT:

Background

Identifying immunologic mechanisms that contribute to premature cardiovascular disease (CVD) among HIV-positive patients will inform prevention strategies.

Methods

Coronary artery calcium (CAC) progression was studied in an HIV cohort. Immunophenotypes were measured on baseline cryopreserved peripheral blood mononuclear cells using multicolor flow cytometry. Logistic regression identified predictors of CAC progression after adjusting for traditional and HIV-related risk factors.

Results

Baseline characteristics for the analysis cohort (n=436) were median age 42 years, median CD4 cell count 481 cells/μl, and 78% receiving antiretroviral therapy. Higher frequencies of CD16 monocytes were associated with greater likelihood of CAC progression, after adjusting f

SUBMITTER: Baker JV 

PROVIDER: S-EPMC4199584 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature