Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients.

ABSTRACT:

Background and objective

The immune and infectious alterations occurring in periodontitis have been shown to alter the development and severity of cardiovascular disease. One of these relationships is the translocation of oral bacteria to atheroma plaques, thereby promoting plaque development. Thus, the aim of this study was to assess, by 16s cloning and sequencing, the microbial diversity of the subgingival environment and atheroma plaques of patients concomitantly suffering from periodontitis and obstructive coronary artery atherosclerosis (OCAA).

Methods

Subgingival biofilm and coronary balloons used in percutaneous transluminal coronary angioplasty were collected from 18 subjects presenting with generalized moderate to severe periodontitis and OCAA. DNA was extracted and

SUBMITTER: Serra e Silva Filho W 

PROVIDER: S-EPMC4199612 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature