CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes.

ABSTRACT: The gram-positive human pathogen Streptococcus pyogenes (group A streptococcus [GAS]) causes diseases ranging from mild and often self-limiting infections of the skin or throat to invasive and life-threatening illnesses. To cause such diverse types of disease, the GAS must be able to sense adverse environments and regulate its gene expression accordingly. The CovR/S two-component signal transduction regulatory system in GAS represses about 15% of the GAS genome, including many genes involved in virulence, in response to the environment. We report that CovR is still able to repress transcription from several promoters in the absence of the putative histidine kinase sensor for this system, CovS. We also show that a phosphorylation site mutant (D53A) of CovR is unable to repress gene expressi

SUBMITTER: Dalton TL 

PROVIDER: S-EPMC419969 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature