Angiogenesis interactome and time course microarray data reveal the distinct activation patterns in endothelial cells.

ABSTRACT: Angiogenesis involves stimulation of endothelial cells (EC) by various cytokines and growth factors, but the signaling mechanisms are not completely understood. Combining dynamic gene expression time-course data for stimulated EC with protein-protein interactions associated with angiogenesis (the "angiome") could reveal how different stimuli result in different patterns of network activation and could implicate signaling intermediates as points for control or intervention. We constructed the protein-protein interaction networks of positive and negative regulation of angiogenesis comprising 367 and 245 proteins, respectively. We used five published gene expression datasets derived from in vitro assays using different types of blood endothelial cells stimulated by VEGFA (vascular endothelial

SUBMITTER: Chu LH 

PROVIDER: S-EPMC4199761 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature