Myosins VIII and XI play distinct roles in reproduction and transport of tobacco mosaic virus.

ABSTRACT: Viruses are obligatory parasites that depend on host cellular factors for their replication as well as for their local and systemic movement to establish infection. Although myosin motors are thought to contribute to plant virus infection, their exact roles in the specific infection steps have not been addressed. Here we investigated the replication, cell-to-cell and systemic spread of Tobacco mosaic virus (TMV) using dominant negative inhibition of myosin activity. We found that interference with the functions of three class VIII myosins and two class XI myosins significantly reduced the local and long-distance transport of the virus. We further determined that the inactivation of myosins XI-2 and XI-K affected the structure and dynamic behavior of the ER leading to aggregation of the vir

SUBMITTER: Amari K 

PROVIDER: S-EPMC4199776 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature