A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes.

ABSTRACT: Subtelomeric duplications of an obscure tubulin "genic" segment located near the telomere of human chromosome 4q35 have occurred at different evolutionary time points within the last 25 million years of the catarrhine (i.e., hominoid and Old World monkey) evolution. The analyses of these segments reported here indicate an exceptional level of evolutionary instability. Substantial intra- and interspecific differences in copy number and distribution are observed among cercopithecoid (Old World monkey) and hominoid genomes. Characterization of the hominoid duplicated segments reveals a strong positional bias within pericentromeric and subtelomeric regions of the genome. On the basis of phylogenetic analysis from predicted proteins and comparisons of nucleotide-substitution rates, we present e

SUBMITTER: van Geel M 

PROVIDER: S-EPMC419983 | biostudies-literature | 2002 Jan

REPOSITORIES: biostudies-literature