A comprehensive resequence-analysis of 250 kb region of 8q24.21 in men of African ancestry.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified that a ∼1 M region centromeric to the MYC oncogene on chromosome 8q24.21 harbors at least five independent loci associated with prostate cancer risk and additional loci associated with cancers of breast, colon, bladder, and chronic lymphocytic leukemia (CLL). Because GWAS identify genetic markers that may be indirectly associated with disease, fine-mapping based on sequence analysis provides important insights into patterns of linkage disequilibrium (LD) and is critical in defining the optimal variants to nominate for biological follow-up.

Methods

To catalog variation in individuals of African ancestry, we resequenced a region (250 kb; chr8:128,050, 768–128, 300,801, hg19) containing several prostate cancer su

SUBMITTER: Chung CC 

PROVIDER: S-EPMC4199861 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature