Common genetic variations in the vitamin D pathway in relation to blood pressure.

ABSTRACT:

Background

Vitamin D is involved in blood pressure (BP) regulation. Genetic variations may influence the effect of vitamin D on BP, but data from epidemiologic studies remain inconsistent.

Methods

We conducted a comprehensive genetic association study in the Women's Genome Health Study (WGHS) with genome-wide genotype data among 23,294 women of European ancestry and in the International Consortium of Blood Pressure (ICBP) with genome-wide meta-analysis results from 69,395 men and women of European ancestry.

Results

First, we found none of 5 selected vitamin D-related candidate single nucleotide polymorphisms (SNPs) was associated with systolic BP (SBP) or diastolic BP (DBP). Second, in 61 candidate SNPs involved in vitamin D metabolism and signaling, rs1507023 (in RBF

SUBMITTER: Wang L 

PROVIDER: S-EPMC4200063 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature