Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene.

ABSTRACT: Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations are at increased risk of prostate cancer, particularly at an early age. To evaluate the contribution of BRCA2 mutations to early-onset prostate cancer, we screened the complete coding sequence of BRCA2 for germline mutations, in 263 men with diagnoses of prostate cancer who were

SUBMITTER: Edwards SM 

PROVIDER: S-EPMC420008 | biostudies-literature | 2003 Jan

REPOSITORIES: biostudies-literature