Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents.

ABSTRACT: Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins. Exportins belong to the karyopherin β superfamily. Exportin-1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), mediates transport of around 220 proteins. In this review, we summarized the development of a new class of antitumor drugs, collectively known as selective inhibitors of nuclear export (SINE). KPT-330 (selinexor) as an oral agent is showing activities in early clinical trials in both solid tumors and hematological malignancies.

SUBMITTER: Parikh K 

PROVIDER: S-EPMC4200201 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature