Neuronal nitric oxide synthase (NOS1) polymorphisms interact with financial hardship to affect depression risk.

ABSTRACT: There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genoty

SUBMITTER: Sarginson JE 

PROVIDER: S-EPMC4200496 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature