Human lung hydrolases delineate Mycobacterium tuberculosis-macrophage interactions and the capacity to control infection.

ABSTRACT: Pulmonary surfactant contains homeostatic and antimicrobial hydrolases. When Mycobacterium tuberculosis is initially deposited in the terminal bronchioles and alveoli, as well as following release from lysed macrophages, bacilli are in intimate contact with these lung surfactant hydrolases. We identified and measured several hydrolases in human alveolar lining fluid and lung tissue that, at their physiological concentrations, dramatically modified the M. tuberculosis cell envelope. Independent of their action time (15 min to 12 h), the effects of the hydrolases on the M. tuberculosis cell envelope resulted in a significant decrease (60-80%) in M. tuberculosis association with, and intracellular growth of the bacteria within, human macrophages. The cell envelope-modifying effects of the hyd

SUBMITTER: Arcos J 

PROVIDER: S-EPMC4201034 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature