CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies.

ABSTRACT:

Motivation

The ability to accurately model protein structures at the atomistic level underpins efforts to understand protein folding, to engineer natural proteins predictably and to design proteins de novo. Homology-based methods are well established and produce impressive results. However, these are limited to structures presented by and resolved for natural proteins. Addressing this problem more widely and deriving truly ab initio models requires mathematical descriptions for protein folds; the means to decorate these with natural, engineered or de novo sequences; and methods to score the resulting models.

Results

We present CCBuilder, a web-based application that tackles the problem for a defined but large class of protein structure, the α-helical coiled coils. CCBuilder

SUBMITTER: Wood CW 

PROVIDER: S-EPMC4201159 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature