Synthesis of unnatural amino acids functionalized with sterically shielded pyrroline nitroxides.

ABSTRACT: A series of unnatural amino acids functionalized with sterically shielded pyrroline nitroxides were synthesized. Their reduction by ascorbate/glutathione indicates that L-cysteine functionalized with gem-diethylpyrroline nitroxide is reduced at the slowest rate and is comparable to that measured for the most resistant to reduction pyrroline and pyrrolidine nitroxides.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4201325 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature