Integrated analysis of microarray data of atherosclerotic plaques: modulation of the ubiquitin-proteasome system.

ABSTRACT: Atherosclerosis is a typical complex multi-factorial disease and many molecules at different levels and pathways were involved in its development. Some studies have investigated the dysregulation in atherosclerosis at mRNA, miRNA or DNA methylation level, respectively. However, to our knowledge, the studies that integrated these data and revealed the abnormal networks of atherosclerosis have not been reported. Using microarray technology, we analyzed the omics data in atherosclerosis at mRNA, miRNA and DNA methylation levels. Our results demonstrated that the global DNA methylation and expression of miRNA/mRNA were significantly decreased in atherosclerotic plaque than in normal vascular tissue. The interaction network constructed using the integrative data revealed many genes, cellular pr

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4201353 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature