Molecular evolutionary and epidemiological dynamics of genotypes 1G and 2B of rubella virus.

ABSTRACT: Rubella Virus (RV), which causes measles-like rashes in children, puts millions of infants at risk of congenital defects across the globe. Employing phylogenetic approaches to the whole genome sequence data and E1 glycoprotein sequence data, the present study reports the substitution rates and dates of emergence of all thirteen previously described rubella genotypes, and gains important insights into the epidemiological dynamics of two geographically widely distributed genotypes 1G and 2B. The overall nucleotide substitution rate of this non-vector-borne RV is in the order of 10-3 substitutions/site/year, which is considerably higher than the substitution rates previously reported for the vector-borne alphaviruses within the same family. Currently circulating strains of RV share a common a

SUBMITTER: Padhi A 

PROVIDER: S-EPMC4201520 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature