Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8.

ABSTRACT:

Background

GTPases of the immunity-associated protein family (GIMAPs) are predominantly expressed in mature lymphocytes. Studies of rodents deficient in GIMAP1, GIMAP4, or GIMAP5 have demonstrated that these GTPases regulate lymphocyte survival. In contrast to the other family members, GIMAP8 contains three potential GTP-binding domains (G-domains), a highly unusual feature suggesting a novel function for this protein. To examine a role for GIMAP8 in lymphocyte biology we examined GIMAP8 expression during lymphocyte development. We also generated a mouse deficient in GIMAP8 and examined lymphocyte development and function.

Principal findings

We show that GIMAP8 is expressed in the very early and late stages of T cell development in the thymus, at late stages during B cell de

SUBMITTER: Webb LM 

PROVIDER: S-EPMC4201521 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature