The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape.

ABSTRACT: Pontin (also known as RUVBL1 and RVB1) and Reptin (also called RUVBL2 and RVB2) are related members of the large AAA+ (adenosine triphosphatase associated with diverse cellular activities) superfamily of conserved proteins. Various cellular functions depend on Pontin and Reptin, mostly because of their functions in the assembly of protein complexes that play a role in the regulation of cellular energetic metabolism, transcription, chromatin remodeling, and the DNA damage response. Little is known, though, about the interconnections between these multiple functions, how the relevant signaling pathways are regulated, whether the interconnections are affected in human disease, and whether components of these pathways are suitable targets for therapeutic intervention. The First International W

SUBMITTER: Rosenbaum J 

PROVIDER: S-EPMC4201591 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature