Disturbed vesicular trafficking of membrane proteins in prion disease.

ABSTRACT: The pathogenic mechanism of prion diseases remains unknown. We recently reported that prion infection disturbs post-Golgi trafficking of certain types of membrane proteins to the cell surface, resulting in reduced surface expression of membrane proteins and abrogating the signal from the proteins. The surface expression of the membrane proteins was reduced in the brains of mice inoculated with prions, well before abnormal symptoms became evident. Prions or pathogenic prion proteins were mainly detected in endosomal compartments, being particularly abundant in recycling endosomes. Some newly synthesized membrane proteins are delivered to the surface from the Golgi apparatus through recycling endosomes, and some endocytosed membrane proteins are delivered back to the surface through recyclin

SUBMITTER: Uchiyama K 

PROVIDER: S-EPMC4201611 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature