Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis.

ABSTRACT: The tumor suppressor protein prostate apoptosis response-4 (Par-4), which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds vimentin, displaces Par-4 from vimentin for secretion and triggers the efficient paracrine apoptosis of diverse cancer cells. Thus, targeting vimentin with Par-4 secretagogues efficiently induces paracrine apoptosis of tumor cells.

SUBMITTER: Burikhanov R 

PROVIDER: S-EPMC4201913 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature