Initiation of TNF inhibitor therapy and change in physiologic measures in psoriasis.

ABSTRACT:

Background

Psoriasis may predispose to cardiovascular disease and diabetes. However, the role of tumor necrosis factor (TNF) inhibitor in mediating this risk is controversial.

Objective

To assess this relationship, we estimated change in metabolic physiologic measures before and after initiation of TNF inhibitor therapy compared with methotrexate (MTX) therapy among psoriasis patients.

Methods

We conducted a retrospective cohort study, 2007-2012, using computerized clinical data for 1274 new users of TNF inhibitor and 979 new users of MTX therapy to compare change in blood pressure, lipids, triglycerides, fasting plasma glucose and body mass index (BMI) before and after start of TNF inhibitors or MTX. The study was restricted to new users. We computed within-person ch

SUBMITTER: Wu JJ 

PROVIDER: S-EPMC4201939 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature