Comparative genomics of Saccharomyces cerevisiae natural isolates for bioenergy production.

ABSTRACT: Lignocellulosic plant material is a viable source of biomass to produce alternative energy including ethanol and other biofuels. However, several factors—including toxic by products from biomass pretreatment and poor fermentation of xylose and other pentose sugars—currently limit the efficiency of microbial biofuel production. To begin to understand the genetic basis of desirable traits, we characterized three strains of Saccharomyces cerevisiae with robust growth in a pretreated lignocellulosic hydrolysate or tolerance to stress conditions relevant to industrial biofuel production, through genome and transcriptome sequencing analysis. All stress resistant strains were highly mosaic, suggesting that genetic admixture may contribute to novel allele combinations underlying these phenotypes.

SUBMITTER: Wohlbach DJ 

PROVIDER: S-EPMC4202335 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature