Mu opioid receptor gene: new point mutations in opioid addicts.

ABSTRACT:

Introduction

Association between single-nucleotide polymorphisms (SNPs) in mu opioid receptor gene and drug addiction has been shown in various studies. Here, we have evaluated the existence of polymorphisms in exon 3 of this gene in Iranian population and investigated the possible association between these mutations and opioid addiction.

Methods

79 opioid-dependent subjects (55 males, 24 females) and 134 non-addict or control individuals (74 males, 60 females) participated in the study. Genomic DNA was extracted from volunteers' peripheral blood and exon 3 of the mu opioid receptor gene was amplified by polymerase chain reaction (PCR) whose products were then sequenced.

Results

Three different heterozygote polymorphisms were observed in 3 male individuals: 759T > C a

SUBMITTER: Dinarvand A 

PROVIDER: S-EPMC4202600 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature