Fibromyalgia is associated with decreased connectivity between pain- and sensorimotor brain areas.

ABSTRACT: Fibromyalgia (FM) is a syndrome characterized by chronic pain without known peripheral causes. Previously, we have reported dysfunctional pain inhibitory mechanisms for FM patients during pain administration. In this study we employed a seed correlation analysis, independent component analysis (ICA), and an analysis of fractional amplitude of low frequency fluctuations (fALFF) to study differences between a cohort of female FM patients and an age- and sex-matched healthy control group during a resting-state condition. FM patients showed decreased connectivity between thalamus and premotor areas, between the right insula and primary sensorimotor areas, and between supramarginal and prefrontal areas. Individual sensitivity to painful pressure was associated with increased connectivity betwee

SUBMITTER: Flodin P 

PROVIDER: S-EPMC4202907 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature