The role of genetic polymorphisms in antioxidant enzymes and potential antioxidant therapies in neonatal lung disease.

ABSTRACT:

Significance

Oxidative stress is involved in the development of newborn lung diseases, such as bronchopulmonary dysplasia and persistent pulmonary hypertension of the newborn. The activity of antioxidant enzymes (AOEs), which is impaired as a result of prematurity and oxidative injury, may be further affected by specific genetic polymorphisms or an unfavorable combination of more of them.

Recent advances

Genetic polymorphisms of superoxide dismutase and catalase were recently demonstrated to be protective or risk factors for the main complications of prematurity. A lot of research focused on the potential of different antioxidant strategies in the prevention and treatment of lung diseases of the newborn, providing promising results in experimental models.

Critical issues<

SUBMITTER: Dani C 

PROVIDER: S-EPMC4203110 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature