Overdetection of recurrence after radical prostatectomy: estimates based on patient and tumor characteristics.

ABSTRACT:

Purpose

Prostate-specific antigen recurrence (PSA-R) after radical prostatectomy (RP) can occur years before metastasis. This study estimates the chance that an untreated PSA-R would not progress to clinical metastasis within the patient's lifetime, that is, that recurrence is overdetected.

Experimental design

Times from PSA-R to metastasis were estimated from patients with RP treated at Johns Hopkins University (Baltimore, MD) who did not receive salvage treatment (n = 441) at PSA-R. Times to other-cause death were based on U.S. life tables adjusted to reflect other-cause survival among RP cases in the Surveillance, Epidemiology, and End Results (SEER) registry. We used competing risks simulation to estimate lower bounds on the chance that other-cause death would precede cl

SUBMITTER: Xia J 

PROVIDER: S-EPMC4203422 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature