Cell Type Specific Analysis of Human Brain Transcriptome Data to Predict Alterations in Cellular Composition.

ABSTRACT: The central nervous system (CNS) is composed of hundreds of distinct cell types, each expressing different subsets of genes from the genome. High throughput gene expression analysis of the CNS from patients and controls is a common method to screen for potentially pathological molecular mechanisms of psychiatric disease. One mechanism by which gene expression might be seen to vary across samples would be alterations in the cellular composition of the tissue. While the expressions of gene 'markers' for each cell type can provide certain information of cellularity, for many rare cell types markers are not well characterized. Moreover, if only small sets of markers are known, any substantial variation of a marker's expression pattern due to experiment conditions would result in poor sensitivi

SUBMITTER: Xu X 

PROVIDER: S-EPMC4203443 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature