Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells.

ABSTRACT: Ionizing radiation induces cellular senescence to suppress cancer cell proliferation. However, it also induces deleterious bystander effects in the unirradiated neighboring cells through the release of senescence-associated secretory phenotypes (SASPs) that promote tumor progression. Although autophagy has been reported to promote senescence, its role is still unclear. We previously showed that radiation induces senescence in PTTG1-depleted cancer cells. In this study, we found that autophagy was required for the radiation-induced senescence in PTTG1-depleted breast cancer cells. Inhibition of autophagy caused the cells to switch from radiation-induced senescence to apoptosis. Senescent cancer cells exerted bystander effects by promoting the invasion and migration of unirradiated cells thr

SUBMITTER: Huang YH 

PROVIDER: S-EPMC4203548 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature