Relationship between SERPING1 rs2511989 polymorphism and age-related macular degeneration risk: a meta-analysis.

ABSTRACT:

Purpose

We conducted a meta-analysis aiming to evaluate the relationship between a common polymorphism (rs2511989 G>A) in the SERPING1 gene and the risk of age-related macular degeneration (AMD).

Methods

The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1, 2013, without any language restrictions. A meta-analysis was conducted using STATA 12.0 software. We calculated a crude odds ratio (OR) with a 95% confidence interval (95% CI) to evaluate the relationships under five genetic models.

Results

Seven case-control studies with a total of 7,159 patients with AMD and 5,797 healthy subjects met the inclusion criteria. The results of our meta-analysis showed tha

SUBMITTER: Ma YB 

PROVIDER: S-EPMC4203579 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature