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Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment.

ABSTRACT: The PI3K/AKT/mTOR pathway is commonly activated in non-small-cell lung cancer. It plays important roles in promoting oncogenesis in lung cancer and mediating resistance to EGF receptor tyrosine kinase inhibitors. Targeted agents against the components of this pathway are currently in development and their clinical benefits remain to be defined. This review provides an overview of the pathway dysregulation and novel agents targeting the pathway in lung cancer. In addition, potential predictive biomarkers guiding patient selection for targeted PI3K/AKT/mTOR inhibition is also discussed.

SUBMITTER: Cheng H 

PROVIDER: S-EPMC4203662 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment.

Cheng Haiying H   Shcherba Marina M   Pendurti Gopichand G   Liang Yuanxin Y   Piperdi Bilal B   Perez-Soler Roman R  

Lung cancer management 20140101 1

The PI3K/AKT/mTOR pathway is commonly activated in non-small-cell lung cancer. It plays important roles in promoting oncogenesis in lung cancer and mediating resistance to EGF receptor tyrosine kinase inhibitors. Targeted agents against the components of this pathway are currently in development and their clinical benefits remain to be defined. This review provides an overview of the pathway dysregulation and novel agents targeting the pathway in lung cancer. In addition, potential predictive bi  ...[more]

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