ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.

ABSTRACT: A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis in vivo, indicating its unique advantages for tissue engineering applications.

SUBMITTER: Lee SH 

PROVIDER: S-EPMC4203664 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature