Specific microbiome changes in a mouse model of parenteral nutrition associated liver injury and intestinal inflammation.

ABSTRACT:

Background

Parenteral nutrition (PN) has been a life-saving treatment in infants intolerant of enteral feedings. However, PN is associated with liver injury (PN Associated Liver Injury: PNALI) in a significant number of PN-dependent infants. We have previously reported a novel PNALI mouse model in which PN infusion combined with intestinal injury results in liver injury. In this model, lipopolysaccharide activation of toll-like receptor 4 signaling, soy oil-derived plant sterols, and pro-inflammatory activation of Kupffer cells (KCs) played key roles. The objective of this study was to explore changes in the intestinal microbiome associated with PNALI.

Methodology and principal findings

Microbiome analysis in the PNALI mouse identified specific alterations within colonic mic

SUBMITTER: Harris JK 

PROVIDER: S-EPMC4203793 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature