Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes.

ABSTRACT:

Background

Gene expression is epigenetically regulated by a combination of histone modifications and methylation of CpG dinucleotides in promoters. In normal cells, CpG-rich promoters are typically unmethylated, marked with histone modifications such as H3K4me3, and are highly active. During neoplastic transformation, CpG dinucleotides of CG-rich promoters become aberrantly methylated, corresponding with the removal of active histone modifications and transcriptional silencing. Outside of promoter regions, distal enhancers play a major role in the cell type-specific regulation of gene expression. Enhancers, which function by bringing activating complexes to promoters through chromosomal looping, are also modulated by a combination of DNA methylation and histone modifications.

Re

SUBMITTER: Blattler A 

PROVIDER: S-EPMC4203885 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature