Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation.

ABSTRACT:

Background

Protein synthesis is tightly regulated and alterations to translation are characteristic of many cancers.Translation regulation is largely exerted at initiation through the eukaryotic translation initiation factor 4 F (eIF4F). eIF4F is pivotal for oncogenic signaling as it integrates mitogenic signals to amplify production of pro-growth and pro-survival factors. Convergence of these signals on eIF4F positions this factor as a gatekeeper of malignant fate. While the oncogenic properties of eIF4F have been characterized, genome-wide evaluation of eIF4F translational output is incomplete yet critical for developing novel translation-targeted therapies.

Results

To understand the impact of eIF4F on malignancy, we utilized a genome-wide ribosome profiling approach to id

SUBMITTER: Rubio CA 

PROVIDER: S-EPMC4203936 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature