HCV, but not HIV, is a risk factor for cerebral small vessel disease.

ABSTRACT:

Objectives

With the aging of HIV populations, vascular contributions to neuropathogenesis are increasingly important. Indirect analyses of cerebral small vessel disease have been performed, but there have been no direct studies of human brain to elucidate risk factors for arteriolar sclerosis.

Methods

Mean arteriolar wall thickness (sclerotic index, SI) was measured in the deep cerebral white matter of 126 brains (96 HIV+, 30 HIV-). Correlations with SI were performed for age, sex, race, hypertension, hyperlipidemia, diabetes, obesity, cirrhosis, hepatitis C virus (HCV) infection, herpes infection, HIV infection, HIV risk, cocaine use, CD4 count, plasma HIV load, and combination antiretroviral therapy (cART) at the time of death.

Results

Age, hypertension, race, HCV,

SUBMITTER: Morgello S 

PROVIDER: S-EPMC4204233 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature