Investigation of known estimated glomerular filtration rate loci in patients with type 2 diabetes.

ABSTRACT:

Aims

To replicate the association of genetic variants with estimated glomerular filtration rate (GFR) and albuminuria, which has been found in recent genome-wide studies in patients with Type 2 diabetes.

Methods

We evaluated 16 candidate single nucleotide polymorphisms for estimated GFR in 3028 patients with Type 2 diabetes sampled from clinics across Tayside, Scotland, UK, who were included in the Genetics of Diabetes Audit and Research Tayside (GoDARTs) study. These single nucleotide polymorphisms were tested for their association with estimated GFR at entry to the study, with albuminuria, and with time to stage 3B chronic kidney disease (estimated GFR<45 ml/min/1.73 m(2)). We also stratified the effects on estimated GFR in patients with (n = 2096) and without albuminuria

SUBMITTER: Deshmukh HA 

PROVIDER: S-EPMC4204276 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature