Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery.

ABSTRACT: There is an increasing need to control the type, quantity, and timing of growth factors released during tissue healing. Sophisticated delivery systems offering the ability to deliver multiple growth factors with independently tunable kinetics are highly desirable. Here, a multilayered, mineral coated micro-particle (MCMs) platform that can serve as an adaptable dual growth factor delivery system is developed. Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) are bound to the mineral coatings with high binding efficiencies of up to 80%. BMP-2 is firstly bound onto a 1^st mineral coating layer; then VEGF is bound onto a 2^nd mineral coating layer. The release of BMP-2 is sustained over a period of 50 days while the release of VEGF is a typ

SUBMITTER: Yu X 

PROVIDER: S-EPMC4204399 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature