Graph theory analysis of functional brain networks and mobility disability in older adults.

ABSTRACT:

Background

The brain's structural integrity is associated with mobility function in older adults. Changes in function may be evident earlier than changes in structure and may be more directly related to mobility. Therefore, we assessed whether functional brain networks varied with mobility function in older adults.

Methods

Short Physical Performance Battery (SPPB) and resting state functional magnetic resonance imaging were collected on 24 young (mean age = 26.4±5.1) and 48 older (mean age = 72.04±5.1) participants. Older participants were divided into three groups by SPPB score: Low SPPB (score = 7-9), Mid SPPB (score = 10), High SPPB (score = 11-12).Graph theory-based methods were used to characterize and compare brain network organization.

Results

Connectivity in t

SUBMITTER: Hugenschmidt CE 

PROVIDER: S-EPMC4204616 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature