Association between efavirenz as initial therapy for HIV-1 infection and increased risk for suicidal ideation or attempted or completed suicide: an analysis of trial data.

ABSTRACT:

Background

The relationship between efavirenz use and suicidality is not well-defined.

Objective

To compare time to suicidality with efavirenz-containing versus efavirenz-free antiretroviral regimens for initial treatment of HIV.

Design

Participant-level data were analyzed from 4 AIDS Clinical Trials Group, antiretroviral-naive studies conducted from 2001 to 2010. Within each study, participants were randomly assigned to an efavirenz-containing (n = 3241) or efavirenz-free (n = 2091) regimen. (ClinicalTrials.gov: NCT00013520 [A5095], NCT00050895 [A5142], NCT00084136 [A5175], and NCT00118898 [A5202]).

Setting

AIDS Clinical Trials Group sites; 74% of participants enrolled in the United States.

Patients

Antiretroviral-naive participants.

Intervention

SUBMITTER: Mollan KR 

PROVIDER: S-EPMC4204642 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature