Feeder-free derivation of neural crest progenitor cells from human pluripotent stem cells.

ABSTRACT: Human pluripotent stem cells (hPSCs) have great potential for studying human embryonic development, for modeling human diseases in the dish and as a source of transplantable cells for regenerative applications after disease or accidents. Neural crest (NC) cells are the precursors for a large variety of adult somatic cells, such as cells from the peripheral nervous system and glia, melanocytes and mesenchymal cells. They are a valuable source of cells to study aspects of human embryonic development, including cell fate specification and migration. Further differentiation of NC progenitor cells into terminally differentiated cell types offers the possibility to model human diseases in vitro, investigate disease mechanisms and generate cells for regenerative medicine. This article presents th

SUBMITTER: Zeltner N 

PROVIDER: S-EPMC4204793 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature