Childhood maltreatment and combat posttraumatic stress differentially predict fear-related fronto-subcortical connectivity.

ABSTRACT:

Background

Adult posttraumatic stress disorder (PTSD) has been characterized by altered fear-network connectivity. Childhood trauma is a major risk factor for adult PTSD, yet its contribution to fear-network connectivity in PTSD remains unexplored. We examined, within a single model, the contribution of childhood maltreatment, combat exposure, and combat-related posttraumatic stress symptoms (PTSS) to resting-state connectivity (rs-FC) of the amygdala and hippocampus in military veterans.

Methods

Medication-free male veterans (n = 27, average 26.6 years) with a range of PTSS completed resting-state fMRI. Measures including the Clinician-Administered PTSD Scale (CAPS), Childhood Trauma Questionnaire (CTQ), and Combat Exposure Scale (CES) were used to predict rs-FC using multi

SUBMITTER: Birn RM 

PROVIDER: S-EPMC4205190 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature