Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis.

ABSTRACT:

Aim

To investigate the allelic and haplotypic association of reg1alpha gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1alpha polymorphisms.

Methods

We analyzed the polymorphisms in the reg1alpha gene by sequencing the gene including its promoter region in 195 TCP patients and 150 ethnically matched controls, compared their allele and haplotype frequencies, and their association with the pathogenesis and pancreaticolithiasis in TCP and fibro-calculous pancreatic diabetes.

Results

We found 8 reported and 2 novel polymo-rphisms including an insertion-deletion polymorphism in the promoter region of reg1alpha. None of

SUBMITTER: Mahurkar S 

PROVIDER: S-EPMC4205441 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature